Jack de Bruijn works since September 2007 for the European Chemicals Agency in Helsinki where he leads the Risk Management Unit which is part of the Assessment Directorate. Before that he worked at the European Chemicals Bureau of the JRC in Ispra where he was responsible for the coordination of the REACH Implementation Projects related to the development of the guidance documents for industry and authorities.
Mike Penman (Penman Consulting, Belgium)
Mike Penman has over 30 years experience in managing toxicology, regulatory affairs and information technology within major companies (ICI 1976-1997; ExxonMobil 1997-2007) and associated trade associations. Initially laboratory based working on alternatives to long term cancer testing, he moved to provide toxicological and regulatory information services to the whole ICI Group, and then as Senior Toxicology and Product Regulatory Adviser to specific businesses. During this time he was awarded a UK civil honour for “Services to Environmental Safety”. For nearly 10 years Mike worked for ExxonMobil, initially as Senior Toxicology Adviser for Europe, and subsequently as the Technical REACH / GHS Implementation Manager.
Externally Mike is well known, leading science and regulatory teams in the areas of synthetic rubber, olefins, plasticisers and oil refining streams. He was chair of the CONCAWE (refining industry) Task Force for the implementation of REACH. He has been involved in the development of regulatory data bases such as IUCLID and in developing novel techniques for the risk assessment of chemicals and in regulatory developments (ECETOC Targeted Risk Assessment). In addition to trade association work on REACH, he chaired the Programme Management Group contracted to the EU to provide a scoping study on information requirements (RIP 3.3-1) and was a member of the Programme Management Group for the final report.
He has a keen interest in developing science-led practical solutions to problems. This has been demonstrated by the range of research activities he initiated when working within trade groups; and also by the coordination of an EU FP6 project designed to examine the possibility of using novel molecular biology techniques to understand mechanisms of reproductive toxicity, so that they might subsequently be used instead of animal testing.
In May 2007 Mike left ExxonMobil to form a Consultancy company based in Brussels offering services in strategic toxicology and regulatory solutions and management. He is also a Director of Baytouch Ltd, who provides regulatory compliance tools, including REACHsuite, the premier solution for substance management.
Richard D. Phillips (ExxonMobil, Belgium)
Dick received his Ph.D. in Toxicology from the University of Mississippi Medical Center in 1979. He then joined Exxon Corporation in 1979 as a Toxicologist. During his career he has supported a number of ExxonMobil business groups across both petroleum and chemical companies. In addition, he has held a number of management positions within EMBSI including Director of the Toxicology Laboratory (1988-1994) and Director of Toxicology Division (1996-2002). In August, 2002, he became one of two Senior Scientific Advisors in EMBSI and led the development of strategic programs in computational toxicology. He Chaired ExxonMobil’s Occupational Exposure Limit Committee from 1996-2006. In May of 2006, he began an European assignment in Belgium as a Distinguished Advisor leading key programs in industry strategic health effects research, risk assessment and science policy. Dick Chairs the Cefic LRI Strategy Implementation Group, is a member of the ACC LRI Strategic Science Team and the ICCA LRI Planning Group.
Dr. Phillips is a Diplomate of the American Board of Toxicology. He is a member of a number of professional societies including the Society of Toxicology, the American College of Toxicology (on Council) , the Society for Risk Analysis and the International Society of Regulatory Toxicology and Pharmacology and the Toxicology Forum.
Susanne Bremer (JRC ECVAM, Italy)
Susanne Bremer is holding a PhD degree in biology obtained from the Charite University Hospital Berlin in Germany. After post-doctoral research at the Federal Institute for Risk Assessment in Germany, Susanne joint the Institute for Health & Consumer Protection (IHCP) at the European Commission’s Joint Research Centre (JRC) and became a team member of the European Centre for the Validation of Alternative Methods (ECVAM) in 1995. She is coordinating ECVAM’s activities in the area of reproductive toxicity testing involving the validation on several tests for assessing endocrine disrupter activity of chemicals and the development of in vitro toxicity tests based on murine/ human embryonic stem cells. In particular, Susanne is interested in the use of alternative methods in testing batteries/strategies for complex human health endpoints. Further information on ECVAM’s activity can be found at: http://ecvam.jrc.it/
1. The European Partnership for Alternative Approaches to Animal Testing (EPAA) is a joint initiative from the European Commission and a number of companies and trade federations active in various industrial sectors. Susanne Bremer is member of the working group “Prioritisation, promotion and implementation of future research based on the application of the 3Rs.”
2. OECD Validation Management Group for Non-Animal Testing
3. OECD expert group: Expert group on the extended one generation reproductive toxicity study
4. Member of the European projects: “ReProTect”, “InVitroHeart”, “ESNATS”
John Doe (Syngenta, UK)
After having previously worked as a pharmacologist in pharmaceutical industry in the areas of asthma, skin allergy and chronic obstructive pulmonary disease, Dr John Doe joined ICI’s Central Toxicology Laboratory in the late 1970s. He initially worked in inhalation toxicology but then managed studies across the full spectrum of regulatory toxicology including chronic, reproductive and developmental toxicology. He became head of project management and business relationships in the early 1990s and helped to steer CTL through the Zeneca demerger and the merger to form Syngenta in 2000. He has worked in agrochemical toxicology for many years. He became Director of CTL in 2003. In 2006 he became Head of Product Safety for Syngenta, bringing together human and environmental safety. He is Chairman of the Scientific Committee of ECETOC and a member of the UK Government Animal Procedures Committee. Dr Doe has published papers in the fields of immunotoxicity, combustion toxicology, reproductive toxicology and risk assessment.
Tom Hutchinson (Plymouth Marine Laboratory, UK)
Tom Hutchinson is Head of Science for Environment and Health at the Plymouth Marine Laboratory, a collaborative centre of the UK’s Natural Environment Research Council, where he leads a research group addressing climate change, marine contaminants, human pathogens and risk assessment. He has over 20 years industrial R&D experience in the UK and Sweden (ICI, ZENECA and AstraZeneca; 1986-2007), encompassing ecotoxicology and mammalian toxicology. He was also AstraZeneca’s Global Project Leader for using aquatic organisms as alternative models in drug discovery (2004-2006). He has a PhD in immunotoxicology from the University of Plymouth (UK) and holds honorary professorships at Brunel University (UK) and the University of Exeter (UK). Current areas of interest are the risk assessment of emerging chemical contaminants, developmental and reproductive toxicology and systems toxicology (including the use of in vitro and in vivo models to support both environmental risk assessment and also biomedical research). He is a member of the European Science Foundation working group on Marine Pollution and has worked on numerous scientific working groups (ABPI, CEFIC, ECETOC, ECVAM and PhRMA, and Chaired the OECD environmental endocrine disrupters working group from 2000-2005). He is also a Director on BioPartner AS (Stavanger, Norway), providing scientific advice for the offshore energy sector in global marine environments.
Mark Cronin (Liverpool John Moores University, UK)
Mark Cronin is Professor of Predictive Toxicology in the School of Pharmacy and Chemistry at Liverpool John Moores University, England. He has research interests in the development of in silico approaches to predict the toxicity and fate of chemicals. This includes both environmental and human health endpoints.
Much current work is focussed on the requirements of regulatory users of predictive toxicology e.g. for REACH. Of particular interest is the assessment of how appropriate different predictive techniques are, as well as approaches to make toxicological decisions from a variety of in silico, in vitro and in chemico information. Key amongst the development of computational techniques are approaches to form toxicologically and mechanistically meaningful categories of chemicals to allow for read-across. Mark has published one book and over 150 articles on predictive toxicology. In addition he has been involved in various EU projects (such as ReProTect, CAESAR, OSIRIS) as well as serving on European and OECD committees and Working Groups in the area of QSAR.
Andrew Worth (European Commission’s Joint Research Centre, Italy)
Dr Andrew Worth is the leader of the Computational Toxicology Project within the Institute for Health & Consumer Protection (IHCP) at the European Commission’s Joint Research Centre (JRC). Dr Worth has degrees in Physiological Sciences and Linguistics, both from Oxford University, and a PhD in computational toxicology from Liverpool John Moores University. He has been involved in JRC activities on chemical risk assessment, alternative test methods, and computational toxicology. Since 2003, he has led the Computational Toxicology group, which promotes the development, assessment, acceptance and implementation of computational methods suitable for the regulatory assessment of chemicals. Further information on the JRC's Computational Toxicology Project can be found at: http://ecb.jrc.it/qsar/.
Gerrit Schüürmann (UFZ Leipzig & TU Freiberg, Germany)
Professor Gerrit Schüürmann has been at the UFZ Helmholtz Centre for Environmental Research in Leipzig (Germany) since 1992 where he heads the Department of Ecological Chemistry. Moreover, he is Professor of Theoretical and Ecological Chemistry at the Technical University Bergakademie Freiberg (Germany), and Honorary Professor of Chemical Ecotoxicology at the University of Leipzig. His professional activities include positions as editor (Environmental Toxicology and Chemistry) and editorial board member, as member of the German Expert Group for the authorization of pesticides, and as chair of the Expert Group for the Evaluation of Chemicals of the GDCh (German Chemical Society) and GT (Society of Toxicology). His research focuses on qualitative and quantitative structure-activity relation-ships (QSARs) and chemodynamics, employing computational chemistry and chemoinformatics as well as experimental work (chemoassays, bioassays) to study compound partitioning, degradation, reactivity and toxicity. In particular, theoretical methods are developed to identify and characterize the application domain of QSAR models. Gerrit Schüürmann has published over 200 papers, is currently involved in several EU projects, and coordinator of the EU project OSIRIS that develops integrated testing strategies for REACH with a particular focus on non-test methods
Watze de Wolf (DuPont, Belgium)
Dr. Watze de Wolf leads DuPont's Health and Environmental Sciences programme in EMEA. His team is part of the "DuPont Haskell Global Centers for Health & Environmental Sciences", and advises DuPont businesses among others on technical aspects of REACH implementation. Active involvements with the RIP process such as RIP 3.2 CSA/CSR, RIP 3.3-2 Testing Strategies, and RIP 3.4 Data Sharing ensured DuPont is thoroughly prepared for REACH. Watze is a member of the ECETOC Scientific Committee, and Past-President of SETAC, a globally operating non-profit organisation for environmental scientists active as regulators, in industry and the academic world.
Helmut Greim (TU Munich, Germany / chair SCHER)
Helmut Greim was chairman and director of the Institutes of Toxicology at the Technical University (1987-2003) and at GSF-Forschungszentrum für Umwelt und Gesundheit (1975-2000) in Munich. After receiving his M.D. degree in Berlin, he became associate professor of pharmacology and toxicology at the University of Tübingen and research associate professor of Pathology at the Mount Sinai School of Medicine, New York (1970-1973). He was / is also chairman of the German Society of Pharmacology and Toxicology (1982-1985), the Advisory Committee on Existing Chemicals (BUA, 1998-2007), the DFG-Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK, 1992 -2007), chairman of the EU Scientific Committee on Health and Environmental Risks (SCHER) and member of the EU Scientific Committee on Occupational Exposure Limits (SCOEL), Enquète-Commission Environment and Health of the German Parliament (1992-1994). He received the Arnold J. Lehman Award of the Society of Toxicology in 1998. Helmut Greim has over 300 publications in scientific journals.
Theo Vermeire (RIVM, The Netherlands)
Theodorus Gabriël (Theo) Vermeire (1953) studied chemistry and toxicology at the University of Utrecht. He received his MSc and teaching qualifications in 1978. He started his career in risk assessment as toxicologist contributing to projects of the WHO International Programme on Chemical Safety (IPCS) and UNEP International Register of Potentially Toxic Chemicals (currently: UNEP Chemicals). In 1987, he was employed by the National Institute for Public Health and the Environment (RIVM) in Bilthoven, the Netherlands, and served in several scientific and managerial functions up to this day. Major projects were the development of the Netherlands' Uniform System for the Evaluation of Substances (industrial chemicals, plant protection products and biocides) and the European Union System for the Evaluation of Substances (industrial chemicals and biocides). His present position at RIVM is deputy head of the RIVM Expert Centre for Substances. As an expert with a wide knowledge on toxicology and risk assessment, he has been involved in many expert groups developing guidance for risk assessment (e.g. for IPCS/WHO, EU, OECD) and in risk assessment training courses. He is a member of the Scientific Committee of the European Environment Agency and editor of the journal Human and Ecological Risk Assessment.
Frédéric Bois (INERIS, France)
Dr. Frédéric Y. Bois, Pharm.D., PhD., is an internationally known expert in quantitative toxicology and risk assessment. Frédéric has directed, at the University of California at Berkeley and the Lawrence Berkeley Laboratory, several research projects in the United States for the Food and Drug Administration, the National Institute of Health, the Environmental Protection Agency, and the Occupational Safety and Health Administration. Now Scientific Officer at the the Institut National de l’Environnement Industriel et des Risques (INERIS), Frédéric has been a member of the Programme Management Group contracted to the EU to provide a scoping study on information requirements (RIP 3.3-1) and is currently co-ordinating an FP6 integrated project called 2-FUN, on news tools and methodologies for risk assessment.
Frédéric is member of the US National Research Council standing committee on Risk Issues and Reviews, of the Scientific Committee for the Agence Française de Sécurité Sanitaire de l'Environnement et du Travail, and of the French Committee for Precaution and Prevention. He is also a member of the American Chemical Society, the American Association for the Advancement of Science, the Society for Mathematical Biology, the European Science Foundation-EERO Association, the French Statistical Society, the French National Association for Technological Research. He is a recipient of the American Statistical Association "Outstanding Statistical Application Award" and of the French Epidaure Prize for Environmental Health Research.
Han van de Sandt (TNO, The Netherlands)
J.J.M (Han) van de Sandt (1965) is board-certified toxicologist and Manager Research Chemical Safety at TNO Quality of Life (Zeist, The Netherlands). In this position, he is involved in the development and application of new methodologies (hazard and exposure) in chemical risk assessment, closely collaborating with industrial partners and regulatory agencies. He is (co-) author of more than 40 peer-reviewed publications. Within the EU-FP6 project OSIRIS, he is pillar leader of Pilar 4.
Jose V. Tarazona (INIA, Spain)
Dr Jose V. Tarazona, Senior Researcher at the Department of the Environment of INIA, is directly involved in the scientific development of environmental risk assessment protocols. Member of the EU Scientific Advisory body since 1992, is currently Vice-chair of the Scientific Committee on Health and Environmental Risk. Directly involved in the implementation of the REACH Regulation, is Scientific Director of the Spanish REACH Reference Centre and member of the ECHA Risk Assessment Committee.
Ortwin Renn (University of Stuttgart, Germany)
Ortwin Renn serves as full professor and chair of environmental sociology at Stuttgart University. He directs the Interdisciplinary Research Unit for Risk Governance and Sustainable Technology Development (ZIRN) at the University of Stuttgart and the non-profit company DIALOGIK, a research institute for the investigation of communication and participation processes in environmental policy making. Since 2006 Renn has been elected Deputy Dean of the Economics- and Social Science Department and Acting Director of the Institute of Social Sciences at the University of Stuttgart.
Ortwin Renn has a doctoral degree in sociology and social psychology from the University of Cologne. He is a member of the panel on “Public Participation in Environmental Assessment and Decision Making” of the U.S.-National Academy of Sciences in Washington, D.C., an ordinary member of the Berlin-Brandenburg Academy of Sciences (Berlin), the German Academy for Technology and Engineering, and the European Academy of Science and Arts (Vienna and Salzburg). His honours include an honorary doctorate from the Swiss Institute of Technology (ETH Zurich), the "Distinguished Achievement Award" of the Society for Risk Analysis (SRA) and the Outstanding Publication Award from the Environment and Technology Section of the American Sociological Association for the book: "Risk, Uncertainty and Rational Action" co-authored by C. Jaeger, G. Rosa und Th. Webler. Among his many political advisory activities is his chairmanship of the State Commission for Sustainable Development (German State of Baden-Württemberg). Renn is primarily interested in risk governance, political participation and technology assessment. He has published more than 30 books and 250 articles.
Volker Koch (Clariant, Germany)
Volker Koch is responisble for the Environmental Safety Assessment of Chemicals for Clariant and a Senior Expert in the field. He was involved in developing strategies for the PBT and vPvB Assessment especially for substances with exceptional properties like e.g. pigments and antioxidants. He developed recently a PBT Screening Tool supporting a coherent and transparent assessment & documentation. In 2005 Mr. Koch has initiated the development of an EXCEL TGD Spreadsheet Model which allows a transparent Envrionmental Exposure Assessment. Based on this spreadsheet model ECETOC has developed the tool further within the Task Force Targeted Risk Assessment. This ECETOC tool will allow Industry from end of 2008 onwards to carry out a REACH conform Environmental Exposure Assessment together with the establishing of Exposure Scenarios. In addition a Customer tool was established as well allowing Downstream users to check if the amount of a chemical used is safe at their site.
Mr. Koch has a PhD in Organic chemistry from the University of Stuttgart, Germany. He started his professional career 1990 at former Hoechst company in the research of insecticides. In 1989 he took over new responisbilities in the Environmental department of Hoechst. In 1997 he joined Clariant.
Aldert Piersma (RIVM, The Netherlands)
Aldert H. Piersma studied Biology at the University of Utrecht in the Netherlands where he graduated in 1981. Specific expertise was gained in Developmental Biology, Tumour Immunology and Pharmacology. In 1985, he obtained his Ph.D. degree in Medicine at the Erasmus University Rotterdam, as the result of an investigation on the role of fibroblastic reticular cells in the haemopoietic stroma in the regulation of proliferation and differentiation of haemopoietic stem cells in mice. He spent two years as a postdoc at the National Institute for Developmental Biology on the development of a battery of in vitro methods for the identification of teratogenic agents and their mechanisms of action. In 1988 he was appointed as reproductive toxicologist at the National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands, where he has lead the Reproductive Toxicology group since. In 2007 he was appointed part-time Professor of Reproductive and Developmental Toxicology at the Institute for Risk Assessment Sciences, University of Utrecht. He divides his time between research, expert advice and education. Research is primarily aimed at methodology development for the analysis of reproductive toxicity of xenobiotic compounds, with main emphasis on occupational toxicants and drugs, to aid the risk assessment process. Specialist advisor with respect to the interpretation of guideline-based reproductive toxicity test results submitted by industry for compound registration purposes. Published over one hundred abstracts, research papers, reviews and RIVM-reports. Past chairman of the Section Reproductive Toxicology and Teratology of the Netherlands Society of Toxicology. Organizer of the Reproductive Toxicology Course in the Postacademic Course on Toxicology of the Netherlands Open University. Member of the Health Council of the Netherlands, chairing the Committee on Classification & Labelling of reproductive toxicants. European Associate Editor of the Journal Reproductive Toxicology. Council Member of the European Teratology Society (ETS). ETS Prize Winner in 1987. Organizer of the 33d Annual Conference of ETS in Haarlem, the Netherlands, in 2005. Former member of the UK-FSA Committee on Toxicity. Served and serves in Committees and Working Groups of European Union, OECD, and WHO on e.g. Classification and Labelling, development of Test Guidelines and Technical Guidance Documents, Endocrine Disruption, and REACH. Research Partner in a series of EU Research Projects. Current research subjects include Nutrition in Pregnancy and the Prevention of Adult Disease, Endocrine Disruption, Alternatives to Animal Experimentation in Developmental Toxicology and the Application of Transcriptomics and Proteomics, and the Development of Intelligent Testing Strategies for Reproductive Toxicity Assessment in REACH.
Joanna Jaworska (P&G, Belgium)
Joanna received her Masters in Environmental Engineering and PhD in mathematical biology and system analysis from Univ. of Tennesse 1993. Her research interests include: Quantitative Structure-Activity Relationships, Reliability assessments of diagnostic tests, Decision theory, Bayesian statistics, Development of probabilistic RA methods both for effects (extrapolation method) and exposure, cumulative and aggregate human exposure modelling.